At VitaBloom Sciences, we are committed to backing our products with rigorous scientific research. Below, you will find a collection of key studies and findings that highlight the benefits and mechanisms of our supplements.
by Linus Pauling
Presented evidence that high-dose vitamin C supplementation (1,000-3,000 mg/day) reduced the duration and severity of common colds by 20-50%.
by Albert Szent-Györgyi
Awarded for isolating vitamin C from adrenal glands, identifying its chemical structure (ascorbic acid), and demonstrating its essential role in preventing scurvy.
by Irwin Stone
Proposed that high-dose vitamin C therapy (10,000-40,000 mg/day) could treat various diseases, including cancer, cardiovascular disease, and infections, by enhancing collagen production and immune function.
Discovered key aspects of Vitamin C bioavailability and effects.
- Vitamin C's bioavailability is limited by intestinal absorption (~200 mg/day)
- High-dose vitamin C supplementation can achieve pharmacological concentrations in blood plasma
- Vitamin C has pro-oxidant properties at high concentrations
by Englard S, Seifter S.
- Ascorbic acid is a cofactor for several enzymes involved in the biosynthesis of collagen, carnitine, and neurotransmitters.
- It acts as an antioxidant, protecting cells from damage by free radicals.
- Ascorbic acid enhances the absorption of non-heme iron from plant-based foods.
- It plays a role in immune function by supporting various cellular activities of both the innate and adaptive immune systems.
by Vladimir Camarena, Gaofeng Wang
Vitamin C (ascorbate) acts as a cofactor for enzymes involved in DNA and histone demethylation, influencing gene expression and phenotypes. Ascorbate deficiency can affect development and contribute to diseases like neurodegeneration and cancer through epigenetic dysregulation.
- Ascorbate is a cofactor for methylcytosine dioxygenases and JmjC domain-containing histone demethylases.
- Variation in ascorbate bioavailability affects DNA and histone demethylation.
- Ascorbate deficiency impacts tissues differently at various development stages.
- Deficiency may contribute to diseases through epigenetic dysregulation.
by Juan I Young, Stephan Züchner, Gaofeng Wang
Ascorbate influences the genome by regulating epigenomic processes.
- Ascorbate is a cofactor for TET dioxygenases that oxidize 5-methylcytosine.
- JmjC-domain histone demethylases require ascorbate.
- Ascorbate mediates the interface between the genome and environment.
- Redox status impacts ascorbate bioavailability in the nucleus.
by Alexander J Michels, Balz Frei
- Research progress to understand the role of vitamin C in human health has been slow due to flawed study designs.
- Primary issues in human cell culture include high oxygen environment, presence of redox-active transition metal ions, and use of immortalized cell lines without supplemental ascorbic acid.
- Animal models are limited due to endogenous ascorbic acid synthesis, even in genetically altered rodent strains.
- Several flaws in study design endemic to randomized controlled trials and other human studies greatly limit their conclusions and impact.
- Anecdotal evidence of positive and negative health effects of vitamin C is widely accepted but not substantiated.